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Simeticone
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==Pharmacology== Simeticone is a non-systemic [[surfactant]] which decreases the surface tension of gas bubbles in the GI tract.<ref name=":0">{{Cite journal| vauthors = Ingold CJ, Akhondi H |date=January 2021|title=Simethicone|url=https://www.ncbi.nlm.nih.gov/books/NBK555997/|journal=StatPearls [Internet].|pmid=32310457 }}</ref> This allows gas bubbles to leave the GI tract as [[flatulence]] or [[belching]].<ref name=":0" /> Simeticone does not reduce or prevent the formation of gas.<ref>{{cite web|title=Treatment of Gas|url=https://iffgd.org/symptoms-causes/intestinal-gas/treatment.html|publisher=International Foundation for Functional Gastrointestinal Disorders|language=en-gb|date=4 September 2015}}</ref> Its effectiveness has been shown in several [[in vitro]] studies.<ref>{{cite journal | vauthors = Brecević L, Bosan-Kilibarda I, Strajnar F | title = Mechanism of antifoaming action of simethicone | journal = Journal of Applied Toxicology | volume = 14 | issue = 3 | pages = 207–11 | date = May 1994 | pmid = 8083482 | doi = 10.1002/jat.2550140311 | url = https://www.researchgate.net/publication/15114732 | access-date = 30 January 2020 | publisher = Wiley | s2cid = 7453218 }}</ref><ref>{{cite journal | vauthors = Dittrich M, Miederer SE, Havertz B, Krastev R | title = Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro |journal= Journal für Gastroenterologische und Hepatologische Erkrankungen. |trans-title=Defoaming and antifoaming action of simethicone in vitro | language = German | date = 12 May 2010 | volume = 8 | issue = 3 | pages = 19–25 | url = https://www.kup.at/kup/pdf/9192.pdf | publisher=Krause & Pachernegg }}</ref>
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