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Skin condition
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=== Dermis === {{Main|Dermis}} The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the [[papillary dermis]] and the [[reticular dermis]].<ref name="Rapini">{{cite book | vauthors = Rapini RP |title=Practical dermatopathology |publisher=Elsevier Mosby |year=2005 |isbn=0-323-01198-5 }}</ref> The superficial papillary dermis [[wikt:interdigitate|interdigitates]] with the overlying [[rete ridge]]s of the epidermis, between which the two layers interact through the basement membrane zone.<ref name="Rapini" /> Structural components of the dermis are [[collagen]], [[elastic fiber]]s, and [[ground substance]] also called extra fibrillar matrix.<ref name="Rapini" /> Within these components are the pilosebaceous units, arrector pili muscles, and the [[eccrine gland|eccrine]] and [[apocrine gland]]s.<ref name="Fitz" /> The dermis contains two vascular networks that run parallel to the skin surface—one superficial and one deep plexus—which are connected by vertical communicating vessels.<ref name="Fitz" /><ref name="Grant-Kels">{{cite book | vauthors = Grant-Kels JM |title=Color Atlas of Dermatopathology (Dermatology: Clinical & Basic Science) |publisher=Informa Healthcare |year=2007|page=163| isbn=978-0-8493-3794-9 }}</ref> The function of blood vessels within the dermis is fourfold: to supply nutrition, to regulate temperature, to modulate inflammation, and to participate in wound healing.<ref name="LAG">{{cite book | vauthors = Ryan T |chapter=Cutaneous Circulation | veditors = Goldsmith LA |title=Physiology, biochemistry, and molecular biology of the skin |publisher=Oxford University Press |location=New York |edition= 2nd |year=1991 |page=1019 |isbn=0-19-505612-4 }}</ref><ref name="pmid8423379">{{cite journal | vauthors = Swerlick RA, Lawley TJ | title = Role of microvascular endothelial cells in inflammation | journal = The Journal of Investigative Dermatology | volume = 100 | issue = 1 | pages = 111S–115S | date = January 1993 | pmid = 8423379 | doi = 10.1038/jid.1993.33 | doi-access = free }}</ref>
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