Editing Thermoception (section)

=== Molecular basis ===
[[File:Thermoreception 2.png|thumb|300px|Channels shown: [[TRPA1]], [[TRPM8]], [[TRPV4]], [[TRPV3]], [[TRPV1]], [[TRPM3]], [[ANO1]], [[TRPV2]]]]

This area of research has recently received considerable attention with the identification and cloning of the [[Transient Receptor Potential]] (TRP) family of proteins. A number of [[ion channels]] are responsible for thermoception and activate at various temperatures so are therefore responsible for different types of thermal stimuli. [[TRPV1]] is the primary channel associated with noxious heat sensing, as well as the detection of [[capsaicin]]. Innocuous warm sensation is mediated by activation of [[TRPM2]]. Innocuous cool sensation is mediated by activation of [[TRPM8]].<ref name="Tominaga"/> [[TRPA1]] is sometimes sensitive to [[menthol]] and considered to be related to noxious cool sensation, but the mechanism is unclear.<ref name="Tominaga"/>

The [[Nobel Prize in Physiology or Medicine]] in 2021 was attributed to [[David Julius]] (professor at the [[University of California, San Francisco]], USA) and [[Ardem Patapoutian]] (neuroscience professor at [[Scripps Research]] in [[La Jolla, California]], USA) "for their discovery of receptors for temperature and touch".<ref name="Nobel_2021a" /><ref name="Nobel_2021b">{{cite web|url=https://www.nobelprize.org/uploads/2021/10/press-medicineprize2021.pdf|title=The Nobel Prize in Physiology or Medicine|publisher=Nobel Foundation|access-date=2021-10-04}}</ref>