Editing Transient receptor potential channel (section)

===TRPC===
{| class="wikitable"
!Family
!Sub-Family
!Known Taxa<ref name="Peng" /><ref>{{cite journal | vauthors = French AS, Meisner S, Liu H, Weckström M, Torkkeli PH | title = Transcriptome analysis and RNA interference of cockroach phototransduction indicate three opsins and suggest a major role for TRPL channels | journal = Frontiers in Physiology | volume = 6 | pages = 207 | date = 2015 | pmid = 26257659 | pmc = 4513288 | doi = 10.3389/fphys.2015.00207 | doi-access = free }}</ref><ref name="Himmel2">{{cite journal |vauthors=Himmel NJ, Gray TR, Cox DN |date=July 2020 |title=Phylogenetics Identifies Two Eumetazoan TRPM Clades and an Eighth TRP Family, TRP Soromelastatin (TRPS) |journal=Molecular Biology and Evolution |volume=37 |issue=7 |pages=2034–2044 |doi=10.1093/molbev/msaa065 |pmc=7306681 |pmid=32159767 |doi-access=free}}</ref>
|-
|rowspan="11" |TRPC
|[[TRPC1]]
|rowspan="7" |Vertebrates
|-
|[[TRPC2]]
|-
|[[TRPC3]]
|-
|[[TRPC4]]
|-
|[[TRPC5]]
|-
|[[TRPC6]]
|-
|[[TRPC7]]
|-
|TRP
|rowspan="3" |Arthropods
|-
|TRPgamma
|-
|TRPL
|-
|Unknown
|Choanoflagellates, cnidarians, [[xenacoelomorpha|xenacoelomorphs]], [[lophotrochozoa]]ns, and nematodes
|}
TRPC, C for "canonical", is named for being the most closely related to ''Drosophila'' TRP, the namesake of TRP channels.  The phylogeny of TRPC channels has not been resolved in detail, but they are present across animal taxa.  There are actually only six TRPC channels expressed in humans because TRPC2 is found to be expressed solely in mice and is considered a [[Pseudogene|pseudo-gene]] in humans; this is partly due to the role of TRPC2 in detecting pheromones, which mice have an increased ability compared to humans. Mutations in TRPC channels have been associated with respiratory diseases along with [[focal segmental glomerulosclerosis]] in the kidneys.<ref name=":3">{{Cite book|title=TRP channels as therapeutic targets : from basic science to clinical use|others=Szallasi, Arpad, 1958-, McAlexander, M. Allen|isbn=9780124200791|location=Amsterdam [Netherlands]|oclc=912315205| vauthors = Szallasi A |date=2015-04-09}}</ref> All TRPC channels are activated either by [[phospholipase C]] (PLC) or [[Diglyceride|diacyglycerol]] (DAG).