Editing Vesicular monoamine transporter (section)

==Location==
There are two types of VMATs expressed in humans: [[VMAT1]] and [[VMAT2]].<ref name="Wimalasena, K. 2011"/> VMAT1 is expressed mainly in large dense-core vesicles (LDCVs) of the peripheral nervous system. VMAT1 may be found in [[neuroendocrine cell]]s, particularly [[chromaffin cell|chromaffin]] and [[enterochromaffin cells|enterochromaffin]] granules, which are primarily found in the [[adrenal medulla|medulla]] of the [[adrenal gland]]s.

VMAT2 favors [[Gene expression|expression]] in a variety of [[Monoaminergic|monoaminergic cells]] of the [[central nervous system]], such as the brain, [[sympathetic nervous system]], [[mast cells]], {{citation needed span|and cells containing [[histamine]] in the gut.|date=October 2014}} It is prevalent in [[Beta cell|β-cells]],<ref name= "Fei">{{cite journal |author1=Fei H. |author2=Grygoruk A. | year = 2008 | title = Trafficking of vesicular neurotransmitter transporters | journal = Traffic | volume = 9| issue = 9| pages = 1425–36| pmc=2897747 | pmid=18507811 | doi=10.1111/j.1600-0854.2008.00771.x|display-authors=etal}}</ref> expressed in [[platelet|blood platelets]],<ref name="Brunk, I. 2006">{{cite book |author1=Brunk I. |author2=Höltje B. | year = 2006 | title = Regulation of vesicular monoamine and glutamate transporters by vesicle-associated trimeric G-proteins: new jobs for long-known signal transduction molecules | series = Handbook of Experimental Pharmacology | volume = 175 | issue = 175| pages = 305–25 |display-authors=etal|doi=10.1007/3-540-29784-7_15 |pmid=16722242 |isbn=978-3-540-29783-3 }}</ref><ref name="Höltje, M. 2003">{{ cite journal |author1=Höltje M. |author2=Winter S. | title = The vesicular monoamine content regulates VMAT2 activity through Galphaq in mouse platelets. Evidence for autoregulation of vesicular transmitter uptake | journal = Journal of Biological Chemistry | volume = 278 | issue = 18| date= May 2003| pages = 15850–15858 | doi = 10.1074/jbc.M212816200| pmid = 12604601 |display-authors=etal| doi-access = free }}</ref> and co-expressed in chromaffin cells.<ref name="Fei" /> Expression of the two transporters in internal organs seems to differ between species: only VMAT1 is expressed in rat adrenal medulla cells, whereas VMAT2 is the major transporter in bovine adrenal medulla cells.<ref name="Wimalasena, K. 2010">{{cite journal | author = Wimalasena K | year = 2010 | title = Vesicular monoamine transporters: structure-function, pharmacology and medicinal chemistry | journal = Medicinal Research Reviews | volume = 31 | issue = 4| pages = 483–19 | doi=10.1002/med.20187 | pmid=20135628 | pmc=3019297}}</ref>