Editing Z-DNA (section)

===Predicting Z-DNA structure===
It is possible to predict the likelihood of a DNA sequence forming a Z-DNA structure. An algorithm for predicting the propensity of DNA to flip from the B-form to the Z-form, ''ZHunt'', was written by [[P. Shing Ho]] in 1984 at [[Massachusetts Institute of Technology|MIT]].<ref name="pmid3780676">{{cite journal |last1=Ho |first1=P. S. |last2=Ellison |first2=M. J. |last3=Quigley |first3=G. J. |last4=Rich |first4=A. |title=A computer aided thermodynamic approach for predicting the formation of Z-DNA in naturally occurring sequences |journal=EMBO Journal |year=1986 |volume=5 |issue=10 |pages=2737–2744 |pmid=3780676 |pmc=1167176|doi=10.1002/j.1460-2075.1986.tb04558.x }}</ref> This algorithm was later developed by [[Tracy Camp]], [[P. Christoph Champ]], [[Sandor Maurice]], and [[Jeffrey M. Vargason]] for genome-wide mapping of Z-DNA (with Ho as the principal investigator).<ref name=Champ2004>{{cite journal |last1=Champ |first1=P. C. |last2=Maurice |first2=S. |last3=Vargason |first3=J. M. |last4=Camp |first4=T. |last5=Ho |first5=P. S. |title=Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation |journal=Nucleic Acids Research |volume=32 |issue=22 |pages=6501–6510 |year=2004 |pmid=15598822 |doi=10.1093/nar/gkh988 |pmc=545456}}</ref>