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===Excess NMDA antagonism=== Toxicity may also result from the pharmacological properties of the drug; excess [[NMDA]] antagonism can completely block calcium influx into neurons and provoke cell death through [[apoptosis]],<ref>{{Cite web|title=NMDA receptor antagonists and Alzheimer's|url=https://www.webmd.com/alzheimers/guide/nmda-receptor-antagonists|access-date=2021-02-17|website=WebMD|language=en}}</ref> although this is more likely to be a long-term result of chronic solvent use than a consequence of short-term use.
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