Editing Randomized controlled trial (section)

== Criticism ==
A 2018 review of the 10 most cited randomised controlled trials noted poor distribution of background traits, difficulties with blinding, and discussed other assumptions and biases inherent in randomised controlled trials. These include the "unique time period assessment bias", the "background traits remain constant assumption", the "average treatment effects limitation", the "simple treatment at the individual level limitation", the "all preconditions are fully met assumption", the "quantitative variable limitation" and the "placebo only or conventional treatment only limitation".<ref>{{Cite journal |vauthors=Krauss A |date=June 2018 |title=Why all randomised controlled trials produce biased results |journal=Annals of Medicine |volume=50 |issue=4 |pages=312–322 |doi=10.1080/07853890.2018.1453233 |pmid=29616838 |doi-access=free}}</ref>