Editing Group 7 element (section)

== Biological role ==

{{Main article|Manganese in biology}}

Of the group 7 elements, only manganese has a role in the human body. It is an essential trace nutrient, with the body containing approximately 10 [[milligram]]s at any given time. It is present as a [[coenzyme]] in biological processes that include macronutrient metabolism, bone formation, and [[free radical]] defense systems. It is a critical component in dozens of proteins and enzymes.<ref name=":4">{{cite book |doi=10.1515/9783110527872-016 |chapter=Manganese: Its Role in Disease and Health |title=Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic |year=2019 |pages=253–266 |pmid=30855111 |isbn=978-3-11-052787-2 |last1=Erikson |first1=K. M. |last2=Aschner |first2=M. |series=Metal Ions in Life Sciences |volume=19 |publisher=[[De Gruyter]] |s2cid=73725546 }}</ref> The manganese in the human body is mainly concentrated in the bones, and the soft tissue remainder is concentrated in the liver and kidneys.{{sfn|Emsley|2001|pp=[https://archive.org/details/naturesbuildingb0000emsl/page/249 249–253]}} In the human brain, the manganese is bound to manganese [[metalloprotein]]s, most notably [[glutamine synthetase]] in [[astrocyte]]s.<ref>{{cite journal|doi=10.1016/S0165-0173(02)00234-5|title=Manganese action in brain function|date=2003 |last=Takeda |first=A.|journal=Brain Research Reviews|volume=41|issue=1|pmid=12505649|pages=79–87|s2cid=1922613}}</ref> Technetium, rhenium, and bohrium have no known biological roles. Technetium is, however, used in radioimaging.