Editing ABC transporter (section)

===Cross-species subfamilies===
{{missing information|section|Pfam/InterPro mapping (bit hard to make, need them to improve data too)|date=December 2020}}
The following classification system for transmembrane solute transporters has been constructed in the TCDB.<ref name="pmid10839820">{{cite journal | vauthors = Saier MH | title = A functional-phylogenetic classification system for transmembrane solute transporters | journal = Microbiology and Molecular Biology Reviews | volume = 64 | issue = 2 | pages = 354–411 | date = Jun 2000 | pmid = 10839820 | pmc = 98997 | doi = 10.1128/MMBR.64.2.354-411.2000 }}; {{cite web | url = http://www.tcdb.org/search/result.php?tc=3.A.1 | title = 3.A.1 The ATP-binding Cassette (ABC) Superfamily | author =  Saier Lab Bioinformatics Group | work = Transporter Classification Database (TCDB) | publisher = University of California San Diego }}</ref>

Three families of ABC exporters are defined by their evolutionary origins.<ref name="Wang2009"/> ABC1 exporters evolved by intragenic triplication of a 2 TMS precursor (TMS = transmembrane segment.  A "2 TMS" protein has 2 transmembrane segments) to give 6 TMS proteins.  ABC2 exporters evolved by intragenic duplication of a 3 TMS precursor, and ABC3 exporters evolved from a 4 TMS precursor which duplicated either extragenicly to give two 4 TMS proteins, both required for transport function, or intragenicly to give 8 or 10 TMS proteins. The 10 TMS proteins appear to have two extra TMSs between the two 4 TMS repeat units.<ref name="Khwaja">{{cite journal | vauthors = Khwaja M, Ma Q, Saier MH | title = Topological analysis of integral membrane constituents of prokaryotic ABC efflux systems | journal = Research in Microbiology | volume = 156 | issue = 2 | pages = 270–7 | date = Mar 2005 | pmid = 15748994 | doi = 10.1016/j.resmic.2004.07.010 | doi-access = free }}</ref> Most uptake systems (all except 3.A.1.21) are of the ABC2 type, divided into type I and type II by the way they handle nucleotides. A special subfamily of ABC2 importers called ECF use a separate subunit for substrate recognition.<ref>{{cite journal |last1=Zheng |first1=WH |last2=Västermark |first2=Å |last3=Shlykov |first3=MA |last4=Reddy |first4=V |last5=Sun |first5=EI |last6=Saier MH |first6=Jr |title=Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters. |journal=BMC Microbiology |date=6 May 2013 |volume=13 |pages=98 |doi=10.1186/1471-2180-13-98 |pmid=23647830 |pmc=3654945 |doi-access=free }}</ref>

ABC1 ({{InterPro|IPR036640}}):
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* 3.A.1.106 The Lipid Exporter (LipidE) Family
* 3.A.1.108 The β-Glucan Exporter (GlucanE) Family
* 3.A.1.109 The Protein-1 Exporter (Prot1E) Family
* 3.A.1.110 The Protein-2 Exporter (Prot2E) Family
* 3.A.1.111 The Peptide-1 Exporter (Pep1E) Family
* 3.A.1.112 The Peptide-2 Exporter (Pep2E) Family
* 3.A.1.113 The Peptide-3 Exporter (Pep3E) Family
* 3.A.1.117 The Drug Exporter-2 (DrugE2) Family
* 3.A.1.118 The Microcin J25 Exporter (McjD) Family
* 3.A.1.119 The Drug/Siderophore Exporter-3 (DrugE3) Family
* 3.A.1.123 The Peptide-4 Exporter (Pep4E) Family
* 3.A.1.127 The AmfS Peptide Exporter (AmfS-E) Family
* 3.A.1.129 The CydDC Cysteine Exporter (CydDC-E) Family
* 3.A.1.135 The Drug Exporter-4 (DrugE4) Family
* 3.A.1.139 The UDP-Glucose Exporter (U-GlcE) Family (UPF0014 Family)
* 3.A.1.201 The Multidrug Resistance Exporter (MDR) Family (ABCB)
* 3.A.1.202 The Cystic Fibrosis Transmembrane Conductance Exporter (CFTR) Family (ABCC)
* 3.A.1.203 The Peroxysomal Fatty Acyl CoA Transporter (P-FAT) Family (ABCD)
* 3.A.1.206 The a-Factor Sex Pheromone Exporter (STE) Family (ABCB)
* 3.A.1.208 The Drug Conjugate Transporter (DCT) Family (ABCC) (Dębska et al., 2011)
* 3.A.1.209 The MHC Peptide Transporter (TAP) Family (ABCB)
* 3.A.1.210 The Heavy Metal Transporter (HMT) Family (ABCB)
* 3.A.1.212 The Mitochondrial Peptide Exporter (MPE) Family (ABCB)
* 3.A.1.21 The Siderophore-Fe3+ '''Uptake''' Transporter (SIUT) Family
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ABC2 ({{InterPro|IPR000412}} [partial]):
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* 3.A.1.101 The Capsular Polysaccharide Exporter (CPSE) Family
* 3.A.1.102 The Lipooligosaccharide Exporter (LOSE) Family
* 3.A.1.103 The Lipopolysaccharide Exporter (LPSE) Family
* 3.A.1.104 The Teichoic Acid Exporter (TAE) Family
* 3.A.1.105 The Drug Exporter-1 (DrugE1) Family
* 3.A.1.107 The Putative Heme Exporter (HemeE) Family
* 3.A.1.115 The Na+ Exporter (NatE) Family
* 3.A.1.116 The Microcin B17 Exporter (McbE) Family
* 3.A.1.124 The 3-component Peptide-5 Exporter (Pep5E) Family
* 3.A.1.126 The β-Exotoxin I Exporter (βETE) Family
* 3.A.1.128 The SkfA Peptide Exporter (SkfA-E) Family
* 3.A.1.130 The Multidrug/Hemolysin Exporter (MHE) Family
* 3.A.1.131 The Bacitracin Resistance (Bcr) Family
* 3.A.1.132 The Gliding Motility ABC Transporter (Gld) Family
* 3.A.1.133 The Peptide-6 Exporter (Pep6E) Family
* 3.A.1.138 The Unknown ABC-2-type (ABC2-1) Family
* 3.A.1.141 The Ethyl Viologen Exporter (EVE) Family (DUF990 Family; {{InterPro|IPR010390}})
* 3.A.1.142 The Glycolipid Flippase (G.L.Flippase) Family
* 3.A.1.143 The Exoprotein Secretion System (EcsAB(C))
* 3.A.1.144:  Functionally Uncharacterized ABC2-1 (ABC2-1) Family
* 3.A.1.145:  Peptidase Fused Functionally Uncharacterized ABC2-2 (ABC2-2) Family
* 3.A.1.146:  The actinorhodin (ACT) and undecylprodigiosin (RED) exporter (ARE) family
* 3.A.1.147:  Functionally Uncharacterized ABC2-2 (ABC2-2) Family
* 3.A.1.148:  Functionally Uncharacterized ABC2-3 (ABC2-3) Family
* 3.A.1.149:  Functionally Uncharacterized ABC2-4 (ABC2-4) Family
* 3.A.1.150:  Functionally Uncharacterized ABC2-5 (ABC2-5) Family
* 3.A.1.151:  Functionally Uncharacterized ABC2-6 (ABC2-6) Family
* 3.A.1.152:  The lipopolysaccharide export (LptBFG) Family ({{InterPro|IPR005495}})
* 3.A.1.204 The Eye Pigment Precursor Transporter (EPP) Family (ABCG)
* 3.A.1.205 The Pleiotropic Drug Resistance (PDR) Family (ABCG)
* 3.A.1.211 The Cholesterol/Phospholipid/Retinal (CPR) Flippase Family (ABCA)
* 9.B.74      The Phage Infection Protein (PIP) Family
* ''all uptake systems'' (3.A.1.1 - 3.A.1.34 except 3.A.1.21) 
** 3.A.1.1 Carbohydrate Uptake Transporter-1 (CUT1)
** 3.A.1.2 Carbohydrate Uptake Transporter-2 (CUT2)
** 3.A.1.3 Polar Amino Acid Uptake Transporter (PAAT)
** 3.A.1.4 Hydrophobic Amino Acid Uptake Transporter (HAAT)
** 3.A.1.5 Peptide/Opine/Nickel Uptake Transporter (PepT)
** 3.A.1.6 Sulfate/Tungstate Uptake Transporter (SulT)
** 3.A.1.7 Phosphate Uptake Transporter (PhoT)
** 3.A.1.8 Molybdate Uptake Transporter (MolT)
** 3.A.1.9 Phosphonate Uptake Transporter (PhnT)
** 3.A.1.10 Ferric Iron Uptake Transporter (FeT)
** 3.A.1.11 Polyamine/Opine/Phosphonate Uptake Transporter (POPT)
** 3.A.1.12 Quaternary Amine Uptake Transporter (QAT)
** 3.A.1.13 Vitamin B<sub>12</sub> Uptake Transporter (B12T)
** 3.A.1.14 Iron Chelate Uptake Transporter (FeCT)
** 3.A.1.15 Manganese/Zinc/Iron Chelate Uptake Transporter (MZT)
** 3.A.1.16 Nitrate/Nitrite/Cyanate Uptake Transporter (NitT)
** 3.A.1.17 Taurine Uptake Transporter (TauT)
** 3.A.1.19 Thiamin Uptake Transporter (ThiT)
** 3.A.1.20 Brachyspira Iron Transporter (BIT)
** 3.A.1.21 Siderophore-Fe3+ Uptake Transporter (SIUT)
** 3.A.1.24  The Methionine Uptake Transporter (MUT) Family (Similar to 3.A.1.3 and 3.A.1.12)
** 3.A.1.27  The γ-Hexachlorocyclohexane (HCH) Family (Similar to 3.A.1.24 and 3.A.1.12)
** 3.A.1.34  The Tryptophan (TrpXYZ) Family
** ''ECF uptake systems''
*** 3.A.1.18 The Cobalt Uptake Transporter (CoT) Family 
*** 3.A.1.22 The Nickel Uptake Transporter (NiT) Family
*** 3.A.1.23 The Nickel/Cobalt Uptake Transporter (NiCoT) Family
*** 3.A.1.25 The Biotin Uptake Transporter (BioMNY) Family
*** 3.A.1.26 The Putative Thiamine Uptake Transporter (ThiW) Family
*** 3.A.1.28 The Queuosine (Queuosine) Family
*** 3.A.1.29 The Methionine Precursor (Met-P) Family
*** 3.A.1.30 The Thiamin Precursor (Thi-P) Family
*** 3.A.1.31 The Unknown-ABC1 (U-ABC1) Family
*** 3.A.1.32 The Cobalamin Precursor (B12-P) Family
*** 3.A.1.33 The Methylthioadenosine (MTA) Family
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ABC3 ({{InterPro|IPR003838}}):
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* 3.A.1.114 The Probable Glycolipid Exporter (DevE) Family
* 3.A.1.122 The Macrolide Exporter (MacB) Family
* 3.A.1.125 The Lipoprotein Translocase (LPT) Family
* 3.A.1.134 The Peptide-7 Exporter (Pep7E) Family
* 3.A.1.136 The Uncharacterized ABC-3-type (U-ABC3-1) Family
* 3.A.1.137 The Uncharacterized ABC-3-type (U-ABC3-2) Family
* 3.A.1.140 The FtsX/FtsE Septation (FtsX/FtsE) Family
* 3.A.1.207 The Eukaryotic ABC3 (E-ABC3) Family
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