Editing Candida albicans (section)

===Bimolecular fluorescence complementation (BiFC)===

Besides the C2H system, a [[bimolecular fluorescence complementation|BiFC]] system has been developed to study protein-protein interactions in ''C. albicans''. With this systems protein interactions can be studied in their native sub cellular location contrary to a C2H system in which the proteins are forced into the nucleus. With BiFC one can study for example protein interactions that take place at the cell membrane or vacuolar membrane.<ref name="frontiersin.org"/><ref>{{cite journal | vauthors = Subotić A, Swinnen E, Demuyser L, De Keersmaecker H, Mizuno H, Tournu H, Van Dijck P | title = A Bimolecular Fluorescence Complementation Tool for Identification of Protein-Protein Interactions in ''Candida albicans'' | journal = G3 | volume = 7 | issue = 10 | pages = 3509–3520 | date = October 2017 | pmid = 28860184 | pmc = 5633398 | doi = 10.1534/g3.117.300149 }}</ref><ref>{{cite journal | vauthors = Mamouei Z, Zeng G, Wang YM, Wang Y | title = Candida albicans possess a highly versatile and dynamic high-affinity iron transport system important for its commensal-pathogenic lifestyle | journal = Molecular Microbiology | volume = 106 | issue = 6 | pages = 986–998 | date = December 2017 | pmid = 29030877 | doi = 10.1111/mmi.13864 | doi-access = free }}</ref>