Editing MicroRNA (section)

==Target prediction==
{{See also|List of RNA structure prediction software#Inter molecular interactions: MicroRNA:UTR}}miRNAs can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. It is of key importance to identify the miRNA targets accurately.<ref name="pmid23591837">{{cite journal | vauthors = Zheng H, Fu R, Wang JT, Liu Q, Chen H, Jiang SW | title = Advances in the techniques for the prediction of microRNA targets | journal = International Journal of Molecular Sciences | volume = 14 | issue = 4 | pages = 8179–87 | date = April 2013 | pmid = 23591837 | pmc = 3645737 | doi = 10.3390/ijms14048179 | doi-access = free }}</ref> A comparison of the predictive performance of eighteen [[in silico]] algorithms is available.<ref>{{cite journal | vauthors = Agarwal V, Bell GW, Nam JW, Bartel DP | title = Predicting effective microRNA target sites in mammalian mRNAs | journal = eLife | volume = 4 | pages = e05005 | date = August 2015 | pmid = 26267216 | pmc = 4532895 | doi = 10.7554/eLife.05005 | doi-access = free }}</ref> Large scale studies of functional miRNA targeting suggest that many functional miRNAs can be missed by target prediction algorithms.<ref name="pmid30207063" />