Editing Notch signaling pathway (section)

=== Liver cancer ===
In [[hepatocellular carcinoma]], for instance, it was suggesting that [[AXIN1]] mutations would provoke Notch signaling pathway activation, fostering the cancer development, but a recent study demonstrated that such an effect cannot be detected.<ref> {{cite journal | vauthors = Zhang R, Li S, Schippers K, Eimers B, Niu J, Hornung BV, van den Hout MC, van Ijcken WF, Peppelenbosch MP, Smits R| title =  Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines. | journal = PLOS ONE | volume = 19 | issue = 6 | pages = e0304607| date = June 2024 | pmid = 38848383 | pmc = 11161089 | doi = 10.1371/journal.pone.0304607 | doi-access = free| bibcode = 2024PLoSO..1904607Z }}</ref> Thus the exact role of Notch signaling in the cancer process awaits further elucidation.