Editing Platelet (section)

===Anti-inflammatory drugs===
Some drugs used to treat inflammation have the unwanted side effect of suppressing normal platelet function. These are the [[non-steroidal anti-inflammatory drugs]] (NSAIDS). [[Aspirin]] irreversibly disrupts platelet function by inhibiting [[cyclooxygenase]]-1 (COX1), and hence normal hemostasis. The resulting platelets are unable to produce new cyclooxygenase because they have no DNA. Normal platelet function does not return until the use of aspirin has ceased and enough of the affected platelets have been replaced by new ones, which can take over a week. [[Ibuprofen]], another [[NSAID]], does not have such a long duration effect, with platelet function usually returning within 24 hours,<ref>{{cite journal |date=April 2005 |title=Summaries for patients. Platelet function after taking Ibuprofen for 1 week |journal=Annals of Internal Medicine |volume=142 |issue=7 |pages=I–54 |doi=10.7326/0003-4819-142-7-200504050-00004 |pmid=15809457 |doi-access=free}}<!-- |access-date=2008-08-26 --></ref> and taking ibuprofen before aspirin prevents the irreversible effects of aspirin.<ref name="pmid6411052">{{cite journal |vauthors=Rao GH, Johnson GG, Reddy KR, White JG |title=Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin |journal=Arteriosclerosis |volume=3 |issue=4 |pages=383–8 |date=1983 |pmid=6411052 |doi=10.1161/01.ATV.3.4.383 |s2cid=3229482 |doi-access=free}}</ref>