Editing Life extension (section)

===Hormone treatment===
The [[anti-aging]] industry offers several [[hormone therapies]]. Some of these have been criticized for possible dangers and a lack of proven effect. For example, the [[American Medical Association]] has been critical of some anti-aging hormone therapies.<ref name=AMA>{{Cite news | vauthors = Japsen B |date=15 June 2009 |title=AMA report questions science behind using hormones as anti-aging treatment |url=https://www.chicagotribune.com/2009/06/15/anti-aging-treatment-on-amas-radar/ |work=[[The Chicago Tribune]] |access-date=17 July 2009}}</ref>

While [[growth hormone]] (GH) decreases with age, the evidence for use of growth hormone as an anti-aging therapy is mixed and based mostly on animal studies. There are mixed reports that GH or [[IGF-1]] modulates the aging process in humans and about whether the direction of its effect is positive or negative.<ref>{{cite journal | vauthors = Sattler FR | title = Growth hormone in the aging male | journal = Best Practice & Research. Clinical Endocrinology & Metabolism | volume = 27 | issue = 4 | pages = 541–555 | date = August 2013 | pmid = 24054930 | pmc = 3940699 | doi = 10.1016/j.beem.2013.05.003 | quote = In animal models, alterations in GH/IGF-1 signaling with reductions in these somatotrophs appear to increase life span. &nbsp;... Administration of IGF-1Eb (mechanogrowth factor) stimulates proliferation of myoblasts and induces muscle hypertrophy. Increases in GH and IGF-1 during adolescence are beneficial for brain and cardiovascular function during the aging process and GH administration during adolescence is vasoprotective and increases life-span.<sup>15</sup>&nbsp;... Studies relating GH and IGF-1 status to longevity provide inconsistent evidence as to whether decreased (somatopause) or high levels (e.g. acromegaly) of these hormones are beneficial or detrimental to longevity.&nbsp;... It is difficult to reconcile the largely protective effects of GH/IGF-1 deficiency on longevity in animals with the inconsistent or deleterious effects of low levels or declining GH/IGF-1 during human aging. }}</ref>

[[Klotho (biology)#Effects on aging|Klotho]]<ref name="Ullah-2018">{{cite journal | vauthors = Ullah M, Sun Z | title = Stem cells and anti-aging genes: double-edged sword-do the same job of life extension | journal = Stem Cell Research & Therapy | volume = 9 | issue = 1 | pages = 3 | date = January 2018 | pmid = 29321045 | pmc = 5763529 | doi = 10.1186/s13287-017-0746-4 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Baranowska B, Kochanowski J | title = The metabolic, neuroprotective cardioprotective and antitumor effects of the Klotho protein | journal = Neuro Endocrinology Letters | volume = 41 | issue = 2 | pages = 69–75 | date = September 2020 | pmid = 33185993 | url = https://pubmed.ncbi.nlm.nih.gov/33185993/ }}</ref> and exerkines<ref name="Chow-2022"/> {{See above|[[#EndogenousCirculatingBiomolecules|above]]}} like [[irisin]]<ref>{{cite journal | vauthors = Fossati C, Papalia R, Torre G, Vadalà G, Borrione P, Grazioli E, Mazzola C, Parisi A, Pigozzi F, Denaro V | display-authors = 6 | title = Frailty of the elderly in orthopaedic surgery and body composition changes: the musculoskeletal crosstalk through irisin | journal = Journal of Biological Regulators and Homeostatic Agents | volume = 34 | issue = 4 Suppl. 3 | pages = 327–335. Congress of the Italian Orthopaedic Research Society | date = July 2020 | pmid = 33261297 }}</ref> are being investigated for potential pro-longevity therapies.