Editing DNA sequencing (section)

==== DNA nanoball sequencing ====
{{Main|DNA nanoball sequencing}}
[[DNA nanoball sequencing]] is a type of high throughput sequencing technology used to determine the entire [[genomic sequence]] of an organism.  The company [[Complete Genomics]] uses this technology to sequence samples submitted by independent researchers.  The method uses [[rolling circle replication]] to amplify small fragments of genomic DNA into DNA nanoballs.  Unchained sequencing by ligation is then used to determine the nucleotide sequence.<ref name = "Drmanac_2010" /> This method of DNA sequencing allows large numbers of DNA nanoballs to be sequenced per run and at low [[reagent]] costs compared to other high-throughput sequencing platforms.<ref>{{cite journal | vauthors = Porreca GJ | title = Genome Sequencing on Nanoballs | journal = Nature Biotechnology | volume = 28 | issue = 1 | pages = 43–44 | year = 2010 | pmid = 20062041 | doi = 10.1038/nbt0110-43 | s2cid = 54557996 }}</ref> However, only short sequences of DNA are determined from each DNA nanoball which makes mapping the short reads to a [[reference genome]] difficult.<ref name = "Drmanac_2010"/>