Editing Hashimoto's thyroiditis (section)

==== Extra-thyroidal effects of autoimmunity hypothesis ====
It is hypothesised that autoimmunity may play some role in euthyroid symptoms.<ref name="Taylor-2024" /><ref name="Chaker-2022" /><ref name="Groenewegen-2021" /> Hypothesised mechanisms include the proposal that TPO-antibody-producing [[Lymphocyte|lymphocytes]] may travel out of the thyroid to other tissue, creating symptoms and inflammation due to [[Cross-reactivity|cross-reaction]],<ref name="Groenewegen-2021" /><ref name="Guldvog I et al">{{cite journal | vauthors = Guldvog I, Reitsma LC, Johnsen L, Lauzike A, Gibbs C, Carlsen E, Lende TH, Narvestad JK, Omdal R, Kvaløy JT, Hoff G, Bernklev T, Søiland H | title = Thyroidectomy Versus Medical Management for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms: A Randomized Trial | journal = Annals of Internal Medicine | volume = 170 | issue = 7 | pages = 453–464 | date = April 2019 | pmid = 30856652 | doi = 10.7326/M18-0284 }}</ref> or "the inflammatory nature of [...] persistently increased circulating cytokine levels."<ref name="Taylor-2024" /> Multiple studies find that antibodies coincide with symptoms even in euthyroid patients,<ref name="Ramos-Levi2023" /><ref name="Groenewegen-2021" /> and higher levels are associated with increased symptoms,<ref name=":6" /> however "the found [[Association (statistics)|association]] does not prove a [[causality]]".<ref name="Groenewegen-2021" /> No treatment currently exists for Hashimoto's autoimmunity, although observed wellbeing improvements after surgical thyroid removal are hypothesised to be due to removing the autoimmune stimulus.<ref name="Klubo-Gwiezdzinska-2022" /><ref name="Guldvog I et al" />