Editing AMPA receptor (section)

==== Agonist Binding and Channel Activation ====
Upon glutamate binding, these two loops move towards each other, leading to pore opening.  The channel opens when two sites are occupied,<ref name="Platt2007">{{cite journal | vauthors = Platt SR | title = The role of glutamate in central nervous system health and disease--a review | journal = Veterinary Journal | volume = 173 | issue = 2 | pages = 278–86 | date = March 2007 | pmid = 16376594 | doi = 10.1016/j.tvjl.2005.11.007 }}</ref> and increases its current as more binding sites are occupied.<ref>{{cite journal | vauthors = Rosenmund C, Stern-Bach Y, Stevens CF | title = The tetrameric structure of a glutamate receptor channel | journal = Science | volume = 280 | issue = 5369 | pages = 1596–9 | date = June 1998 | pmid = 9616121 | doi = 10.1126/science.280.5369.1596 | bibcode = 1998Sci...280.1596R | hdl = 11858/00-001M-0000-0012-FDD8-B | hdl-access = free }}</ref>  This opening allows the influx of [[Sodium ion|sodium (Na⁺)]] and, depending on subunit composition, [[Calcium ion|calcium (Ca²⁺)]] ions into the postsynaptic neuron, leading to depolarization and the propagation of excitatory signals.<ref>{{Cite journal |last1=Hale |first1=W. Dylan |last2=Montaño Romero |first2=Alejandra |last3=Gonzalez |first3=Cuauhtemoc U. |last4=Jayaraman |first4=Vasanthi |last5=Lau |first5=Albert Y. |last6=Huganir |first6=Richard L. |last7=Twomey |first7=Edward C. |date=November 2024 |title=Allosteric competition and inhibition in AMPA receptors |journal=Nature Structural & Molecular Biology |language=en |volume=31 |issue=11 |pages=1669–1679 |doi=10.1038/s41594-024-01328-0 |issn=1545-9993 |pmc=11563869 |pmid=38834914}}</ref> Once open, the channel may undergo rapid desensitization, stopping the current.