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Adrenal cortex
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=== Zona reticularis === The innermost cortical layer, the [[zona reticularis]], produces adrenal androgens, as well as small amounts of estrogens and some glucocorticoids.<ref name=":1" /> The zona reticularis has more of the cofactors required for the [[17,20 lyase|17,20-lyase]] activity of [[17Ξ±-hydroxylase]] than zona fasciculata. Therefore, the zona reticularis makes more [[androgen]]s,<ref name=":0" /> mainly [[dehydroepiandrosterone]] (DHEA), [[DHEA sulfate]] (DHEA-S), and [[androstenedione]] (the precursor to [[testosterone]]) in humans. The secretion of DHEAS is also stimulated by ACTH.<ref name="1995-Hanukoglu-A" />
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