Editing Amitriptyline (section)

===Headache===
Amitriptyline is probably effective for the prevention of periodic [[migraine]] in adults. Amitriptyline is similar in efficacy to [[venlafaxine]] and [[topiramate]] but carries a higher burden of adverse effects than topiramate.<ref name="pmid22529202">{{cite journal | vauthors = Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E | title = Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society | journal = Neurology | volume = 78 | issue = 17 | pages = 1337–1345 | date = April 2012 | pmid = 22529202 | pmc = 3335452 | doi = 10.1212/WNL.0b013e3182535d20 }}</ref> For many patients, even very small doses of amitriptyline are helpful, which may allow for minimization of side effects.<ref name="pmid30137671">{{cite journal | vauthors = Loder E, Rizzoli P | title = Pharmacologic Prevention of Migraine: A Narrative Review of the State of the Art in 2018 | journal = Headache | volume = 58 | issue = Suppl 3 | pages = 218–229 | date = November 2018 | pmid = 30137671 | doi = 10.1111/head.13375 | s2cid = 52071815 }}</ref> Amitriptyline is not significantly different from placebo when used for the prevention of migraine in children.<ref name="pmid31413170">{{cite journal | vauthors = Oskoui M, Pringsheim T, Billinghurst L, Potrebic S, Gersz EM, Gloss D, Holler-Managan Y, Leininger E, Licking N, Mack K, Powers SW, Sowell M, Victorio MC, Yonker M, Zanitsch H, Hershey AD | title = Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society | journal = Neurology | volume = 93 | issue = 11 | pages = 500–509 | date = September 2019 | pmid = 31413170 | pmc = 6746206 | doi = 10.1212/WNL.0000000000008105 }}</ref>

Amitriptyline may reduce the frequency and duration of chronic [[tension headache]], but it is associated with worse adverse effects than [[mirtazapine]]. Overall, amitriptyline is recommended for tension headache [[prophylaxis]], along with lifestyle advice, which should include avoidance of analgesia and caffeine.<ref name="pmid26859719">{{cite journal | vauthors = Ghadiri-Sani M, Silver N | title = Headache (chronic tension-type) | journal = BMJ Clinical Evidence | volume = 2016 | date = February 2016 | pmid = 26859719 | pmc = 4747324 }}</ref>