Editing Asphyxia (section)

===Perinatal asphyxia===
{{Main|Perinatal asphyxia}}
Perinatal asphyxia is the medical condition resulting from deprivation of [[oxygen]] ([[Hypoxia (medical)|hypoxia]]) to a newborn infant long enough to cause apparent harm. It results most commonly from a drop in maternal [[blood pressure]] or interference during [[Childbirth|delivery]] with blood flow to the infant's [[brain]]. This can occur as a result of inadequate [[Circulatory system|circulation]] or [[perfusion]], impaired respiratory effort, or inadequate [[Ventilation (physiology)|ventilation]].<ref name="Davis2">{{cite journal |vauthors=Davis PG, Tan A, O'Donnell CP, Schulze A |year=2004 |title=Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis |journal=Lancet |volume=364 |issue=9442 |pages=1329–33 |doi=10.1016/S0140-6736(04)17189-4 |pmid=15474135 |s2cid=24825982}}</ref> There has long been a scientific debate over whether [[Neonatal resuscitation|newborn infants with asphyxia should be resuscitated]] with 100% oxygen or normal air.<ref name="Davis2" /> It has been demonstrated that high concentrations of oxygen lead to generation of oxygen [[free radicals]], which have a role in [[reperfusion injury]] after asphyxia.<ref>{{cite journal |author-link4=Ola Didrik Saugstad |vauthors=Kutzsche S, Ilves P, Kirkeby OJ, Saugstad OD |date=June 2001 |title=Hydrogen peroxide production in leukocytes during cerebral hypoxia and reoxygenation with 100% or 21% oxygen in newborn piglets |journal=Pediatric Research |volume=49 |issue=6 |pages=834–42 |doi=10.1203/00006450-200106000-00020 |pmid=11385146 |doi-access=free}}</ref> Research by [[Ola Didrik Saugstad]] and others led to new international guidelines on newborn resuscitation in 2010, recommending the use of normal air instead of 100% oxygen.<ref>ILCOR [[Neonatal resuscitation]] Guidelines 2010</ref><ref>{{cite web |title=Norwegian paediatrician honoured by University of Athens |url=http://www.norway.gr/News_and_events/Events/Older-articles/Norwegian-paediatrician-honoured-by-University-of-Athens-/ |archive-url=https://web.archive.org/web/20160304101405if_/http://www.norway.gr/News_and_events/Events/Older-articles/Norwegian-paediatrician-honoured-by-University-of-Athens-/#.Vtlf8C2l1qs |archive-date=4 March 2016 |work=Royal Norwegian Embassy in Athens}}</ref>