Editing Atrioventricular node (section)

===Development===
[[Bone morphogenetic protein]] (BMP) [[cell signaling]] plays a key role in diverse aspects of cardiac differentiation and morphogenesis. (BMPs) are multifunctional signaling molecules critical for the development of AV node. BMP influences AV node development through Alk3 receptor (Activin receptor-like kinase 3). Abnormalities seen in BMP and Alk3 are associated with some cardiovascular diseases like Ebstein's anomaly and AV conduction disease.<ref>{{Cite journal|vauthors=Stroud DM, Gaussin V, Burch JB |title=Abnormal Conduction and Morphology in the Atrioventricular Node of Mice With Atrioventricular Canal–Targeted Deletion of Alk3/Bmpr1a Receptor |journal=Circulation |volume=116 |issue=22 |pages=2535–2643 |date=November 2007 |pmid=17998461|pmc=2947829 |doi=10.1161/CIRCULATIONAHA.107.696583|display-authors=etal}}</ref>