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Autosplenectomy
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==== Pitted erythrocytes ==== Erythrocytes with membrane pits can be indicative of splenic dysfunction as a healthy spleen clears blood of pitted erythrocytes. Pitted erythrocytes can be counted using Normarsky optics.<ref>{{Cite journal|title = Post-splenectomy and hyposplenic states|last = Di Sabatino|first = Antonio|date = April 6, 2011|journal = Lancet|volume = 378|issue = 9785|pages = 86β97|doi = 10.1016/s0140-6736(10)61493-6 |pmid = 21474172|s2cid = 30554953}}</ref> Humans with healthy spleens have less than two percent of their red blood cells contain pits. In comparison, a person with asplenia may have up to 50% of their red blood cells contain pits.<ref>{{Cite web|url=http://www.rbclab.com/Pages/200/210/120%20Pit/210%20120.html|title=Red Blood Cell Pit Count|date=2010|website=Red Blood Cell Lab|publisher=Children's Hospital Oakland Research Institute|access-date=March 2, 2016}}</ref>
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