Editing Bisphosphonate (section)

===Cancer===
Bisphosphonates reduce the risk of fracture and bone pain<ref>{{cite journal |vauthors=Zhu M, Liang R, Pan LH |title=Zoledronate for metastatic bone disease and pain: a meta-analysis of randomized clinical trials |journal=Pain Med |volume=14 |issue=2 |pages=257–64 | date=February 2013|pmid=23279447 |doi=10.1111/pme.12016 |display-authors=etal|doi-access=free }}</ref> in people with breast,<ref name=OCarrigan2017>{{Cite journal|last1=O'Carrigan|first1=Brent|last2=Wong|first2=Matthew Hf|last3=Willson|first3=Melina L.|last4=Stockler|first4=Martin R.|last5=Pavlakis|first5=Nick|last6=Goodwin|first6=Annabel|date=2017|title=Bisphosphonates and other bone agents for breast cancer|journal=The Cochrane Database of Systematic Reviews|volume=10|issue=11|pages=CD003474|doi=10.1002/14651858.CD003474.pub4|issn=1469-493X|pmid=29082518|pmc=6485886}}</ref> lung,<ref>{{cite journal |vauthors=Lopez-Olivo MA, Shah NA, Pratt G, Risser JM, Symanski E, Suarez-Almazor ME |title=Bisphosphonates in the treatment of patients with lung cancer and metastatic bone disease: a systematic review and meta-analysis |journal=Support Care Cancer |volume=20 |issue=11 |pages=2985–98 | date=November 2012|pmid=22956190 |pmc=3691019 |doi=10.1007/s00520-012-1563-z }}</ref> and other metastatic cancers as well as in people with multiple myeloma.<ref>{{cite journal |vauthors=Mhaskar R, Kumar A, Miladinovic B, Djulbegovic B |title=Bisphosphonates in multiple myeloma: a network meta-analysis |journal=Cochrane Database Syst Rev |volume= 2017|pages=CD003188 |year=2017 |issue=12 |pmid=29253322|doi=10.1002/14651858.CD003188.pub4 |pmc=6486151 }}</ref> In breast cancer there is mixed evidence regarding whether bisphosphonates improve survival.<ref name=OCarrigan2017 /><ref>{{cite journal |vauthors=Ben-Aharon I, Vidal L, Rizel S |title=Bisphosphonates in the adjuvant setting of breast cancer therapy--effect on survival: a systematic review and meta-analysis |journal=PLOS ONE |volume=8 |issue=8 |pages=e70044 |year=2013 |pmid=23990894 |pmc=3753308 |doi=10.1371/journal.pone.0070044 |bibcode=2013PLoSO...870044B |display-authors=etal|doi-access=free }}</ref><ref>{{cite journal |vauthors=Zhu J, Zheng Y, Zhou Z |title=Oral adjuvant clodronate therapy could improve overall survival in early breast cancer: results from an updated systematic review and meta-analysis |journal=Eur. J. Cancer |volume=49 |issue=9 |pages=2086–92 | date=June 2013|pmid=23452992 |doi=10.1016/j.ejca.2013.01.021 }}</ref><ref name=VanAcker2015 /> A 2017 Cochrane review found that for people with early breast cancer, bisphosphonate treatment may reduce the risk of the cancer spreading to the person's bone, however, for people who had advanced breast cancer bisphosphonate treatment did not appear to reduce the risk of the cancer spreading to the bone.<ref name=OCarrigan2017 /> Side effects associated with bisphosphonate treatment for people with breast cancer are mild and rare.<ref name=OCarrigan2017 />

Bisphosphonates can also reduce mortality in those with multiple myeloma and prostate cancer.<ref name=VanAcker2015>{{cite journal|last1=Van Acker|first1=HH|last2=Anguille|first2=S|last3=Willemen|first3=Y|last4=Smits|first4=EL|last5=Van Tendeloo|first5=VF|title=Bisphosphonates for cancer treatment: Mechanisms of action and lessons from clinical trials.|journal=Pharmacology & Therapeutics|date=23 November 2015|pmid=26617219|doi=10.1016/j.pharmthera.2015.11.008|volume=158|pages=24–40}}</ref>