Editing Brain-derived neurotrophic factor (section)

=== LNGFR ===

The role of the other BDNF receptor, [[Low-affinity nerve growth factor receptor|p75]], is less clear. While the TrkB receptor interacts with BDNF in a ligand-specific manner, all neurotrophins can interact with the p75 receptor.<ref name="Bartkowska_2007">{{cite journal | vauthors = Bartkowska K, Paquin A, Gauthier AS, Kaplan DR, Miller FD | title = Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development | journal = Development | volume = 134 | issue = 24 | pages = 4369–80 | date = December 2007 | pmid = 18003743 | doi = 10.1242/dev.008227 | doi-access = free }}</ref>  When the p75 receptor is activated, it leads to activation of [[NFkB]] receptor.<ref name="Bartkowska_2007"/>  Thus, neurotrophic signaling may trigger [[apoptosis]] rather than survival pathways in cells expressing the p75 receptor in the absence of Trk receptors.  Recent studies have revealed a truncated isoform of the TrkB receptor (t-TrkB) may act as a dominant negative to the p75 neurotrophin receptor, inhibiting the activity of p75, and preventing BDNF-mediated cell death.<ref name="pmid20955473">{{cite journal | vauthors = Michaelsen K, Zagrebelsky M, Berndt-Huch J, Polack M, Buschler A, Sendtner M, Korte M | title = Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neurons | journal = The European Journal of Neuroscience | volume = 32 | issue = 11 | pages = 1854–65 | date = December 2010 | pmid = 20955473 | doi = 10.1111/j.1460-9568.2010.07460.x | s2cid = 23496332 }}</ref>