Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
CD36
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
=== Posttranslational modification === Besides glycosylation, additional [[post-translational modification]]s have been reported for CD36. CD36 is modified with 4 [[palmitoyl chains]], 2 on each of the two intracellular domains.<ref name="pmid8798390"/> The function of these lipid modifications is currently unknown but they likely promote the association of CD36 with the membrane and possibly [[lipid rafts]] which appear to be important for some CD36 functions.<ref name="pmid12947091">{{cite journal | vauthors = Zeng Y, Tao N, Chung KN, Heuser JE, Lublin DM | title = Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 46 | pages = 45931β6 | date = November 2003 | pmid = 12947091 | doi = 10.1074/jbc.M307722200 | doi-access = free }}</ref><ref name="pmid15496455">{{cite journal | vauthors = Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W | title = FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts | journal = Molecular Biology of the Cell | volume = 16 | issue = 1 | pages = 24β31 | date = January 2005 | pmid = 15496455 | pmc = 539148 | doi = 10.1091/mbc.E04-07-0616 }}</ref> CD36 could be also phosphorylated at Y62, T92, T323,<ref name="urlwww.phosphosite.org">{{cite web | url = http://www.phosphosite.org/proteinAction.do?id=18224&showAllSites=true | title = CD36 (human) protein page |vauthors=Hornbeck PV, Kornhauser JM, Tkachev S, Zhang B, Skrzypek E, Murray B, Latham V, Sullivan M | work = PhosphoSitePlus | publisher = Cell Signaling Technology, Inc. }}</ref> ubiquitinated at K56, K469, K472 and acetylated at K52, K56, K166, K231, K394, K398, K403.<ref name="pmid18353783">{{cite journal | vauthors = Smith J, Su X, El-Maghrabi R, Stahl PD, Abumrad NA | title = Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake | journal = The Journal of Biological Chemistry | volume = 283 | issue = 20 | pages = 13578β85 | date = May 2008 | pmid = 18353783 | pmc = 2376227 | doi = 10.1074/jbc.M800008200 | doi-access = free }}</ref><ref name="pmid23603908">{{cite journal | vauthors = Kuda O, Pietka TA, Demianova Z, Kudova E, Cvacka J, Kopecky J, Abumrad NA | title = Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages | journal = The Journal of Biological Chemistry | volume = 288 | issue = 22 | pages = 15547β55 | date = May 2013 | pmid = 23603908 | pmc = 3668716 | doi = 10.1074/jbc.M113.473298 | doi-access = free }}</ref><ref name="pmid22902405">{{cite journal | vauthors = Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV | display-authors = 6 | title = Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns | journal = Cell Reports | volume = 2 | issue = 2 | pages = 419β31 | date = August 2012 | pmid = 22902405 | pmc = 4103158 | doi = 10.1016/j.celrep.2012.07.006 }}</ref>
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)