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COPII
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==Evolution== In mammals there are two Sar1 genes: ''SAR1A'' and ''SAR1B'' (''SAR1B'' was previously known as ''SARA2''<ref>{{cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=SAR1B|title=''SAR1B'' Gene - Secretion Associated Ras Related GTPase 1B|website=GeneCards: The Human Gene Database|date=4 October 2023|access-date=7 December 2023}}</ref>). In cultured mammalian cells the two Sar1 genes appear redundant; however, in animals SAR1B is uniquely required for the formation of large (over 1 [[micrometre|micrometer]] across) COPII-coated vesicles.<ref name=Peotter2019/> Similarly, mammals express two Sec23 genes: ''SEC23A'' and ''SEC23B''. The two Sec23 isoforms have identical function but are expressed in different body tissues. Both Sec23 proteins can interact with any of the four Sec24 proteins: SEC24A, SEC24B, SEC24C, and SEC24D.<ref name=Peotter2019/>
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