Editing CREB (section)

==Mechanism of action==
A generalized sequence of events is summarized as follows: A signal arrives at the cell surface, activates the corresponding receptor, which leads to the production of a [[second messenger]] such as cAMP or [[calcium|Ca<sup>2+</sup>]], which in turn activates a [[protein kinase]]. This protein kinase translocates to the [[cell nucleus]], where it activates a CREB protein. The activated CREB protein then binds to a CRE region, and is then bound to by [[CREB-binding protein|CBP]] (CREB-binding protein), which coactivates it, allowing it to switch certain genes on or off. The DNA binding of CREB is mediated via its basic leucine zipper domain ([[bZIP domain]]) as depicted in the image. Evidence suggests the β-adrenoceptor (a [[G protein-coupled receptor|G-protein coupled receptor]]) stimulates CREB signalling.<ref>{{Cite journal|last1=Pearce|first1=Alexander|last2=Sanders|first2=Lucy|last3=Brighton|first3=Paul J.|last4=Rana|first4=Shashi|last5=Konje|first5=Justin C.|last6=Willets|first6=Jonathon M.|date=2017-10-01|title=Reciprocal regulation of β2-adrenoceptor-activated cAMP response-element binding protein signalling by arrestin2 and arrestin3|url=https://figshare.com/articles/journal_contribution/Reciprocal_regulation_of_2-adrenoceptor-activated_cAMP_response-element_binding_protein_signalling_by_arrestin2_and_arrestin3/10213043/1/files/18414974.pdf|journal=Cellular Signalling|language=en|volume=38|pages=182–191|doi=10.1016/j.cellsig.2017.07.011|pmid=28733084 |issn=0898-6568}}</ref>