Editing Cannabinoid receptor (section)

=== CB<sub>2</sub> ===
{{Main|Cannabinoid receptor type 2}}

[[Cannabinoid receptor 2 (macrophage)|CB<sub>2</sub>]] receptors are expressed on [[T cell]]s of the [[immune system]], on [[macrophage]]s and [[B cell]]s, in [[Pluripotential hemopoietic stem cell|hematopoietic cells]], and in the brain and CNS (2019).<ref>{{cite book |vauthors=Onaivi J |chapter=Endocannabinoid System Components: Overview and Tissue Distribution |chapter-url=https://doi.org/10.1007/978-3-030-21737-2_1 |title=Recent Advances in Cannabinoid Physiology and Pathology |veditors=Bukiya A |publisher=Springer |location=Cham. |series=Advances in Experimental Medicine and Biology |year=2019 |volume=1162 |pages=1–12 |doi=10.1007/978-3-030-21737-2_1 |pmid=31332731 |isbn=978-3-030-21736-5 |s2cid=198172390 |access-date=19 October 2021 |archive-date=20 April 2023 |archive-url=https://web.archive.org/web/20230420210524/https://link.springer.com/chapter/10.1007/978-3-030-21737-2_1 |url-status=live }}</ref> They also have a function in [[keratinocyte]]s. They are also expressed on peripheral [[nerve]] terminals. These receptors play a role in [[antinociception]], or the relief of [[pain]]. In the brain, they are mainly expressed by [[Microglia|microglial cells]], where their role remains unclear. While the most likely cellular targets and executors of the CB<sub>2</sub> receptor-mediated effects of endocannabinoids or synthetic agonists are the immune and immune-derived cells (e.g. [[leukocytes]], various populations of T and B lymphocytes, [[Monocyte|monocytes]]/[[Macrophage|macrophages]], [[Dendritic cell|dendritic cells]], [[Mast cell|mast cells]], microglia in the brain, [[Kupffer cell|Kupffer cells]] in the liver, [[Astrocyte|astrocytes]], etc.), the number of other potential cellular targets is expanding, now including endothelial and smooth muscle cells, fibroblasts of various origins, cardiomyocytes, and certain neuronal elements of the peripheral or central nervous systems (2011).<ref name="pmid21295074"/>