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Capillary
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==== Continuous ==== Continuous capillaries are continuous in the sense that the endothelial cells provide an uninterrupted lining, and they only allow smaller [[molecule]]s, such as water and [[ion]]s, to pass through their [[intercellular cleft]]s.<ref name="keep">{{cite journal |pmc=4836471|year=2016|last1=Stamatovic|first1=S. M.|title=Junctional proteins of the blood-brain barrier: New insights into function and dysfunction|journal=Tissue Barriers|volume=4|issue=1|pages=e1154641|last2=Johnson|first2=A. M.|last3=Keep|first3=R. F.|last4=Andjelkovic|first4=A. V.|pmid=27141427|doi=10.1080/21688370.2016.1154641}}</ref><ref name="wilhelm">{{cite journal|pmc=4836475|year= 2016|last1=Wilhelm|first1=I.|title=Heterogeneity of the blood-brain barrier|journal=Tissue Barriers|volume=4|issue=1|pages=e1143544|last2=Suciu|first2=M.|last3=Hermenean|first3=A.|last4=Krizbai|first4=I. A.|pmid=27141424|doi= 10.1080/21688370.2016.1143544}}</ref> Lipid-soluble molecules can passively diffuse through the endothelial cell membranes along concentration gradients.<ref name="sarin">{{cite journal |pmc=3234205|year=2010|last1=Sarin|first1= H.|title=Overcoming the challenges in the effective delivery of chemotherapies to CNS solid tumors|journal=Therapeutic Delivery|volume=1|issue=2|pages=289–305|doi=10.4155/tde.10.22|pmid=22163071}}</ref> Continuous capillaries can be further divided into two subtypes: :# Those with numerous transport vesicles, which are found primarily in [[skeletal muscle]]s, fingers, [[gonad]]s, and skin.<ref>{{cite journal |pmid=22574942|year=2012|last1=Michel|first1=C. C.|title=Electron tomography of vesicles|journal=Microcirculation |volume=19|issue=6|pages=473–6|doi=10.1111/j.1549-8719.2012.00191.x|s2cid=205759387|doi-access=free}}</ref> :# Those with few vesicles, which are primarily found in the [[central nervous system]]. These capillaries are a constituent of the [[blood–brain barrier]].<ref name=wilhelm/>
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