Editing Cefalexin (section)

== Interactions ==

Like other [[β-lactam antibiotic]]s, renal excretion of cefalexin is delayed by [[probenecid]].<ref name=AHFS2014/> It is also not recommended to take cefalexin with [[dofetilide]], live [[Cholera vaccine]], [[warfarin]], and [[cholestyramine]].<ref>{{cite web |title=Cephalexin (Oral Route) |url=https://www.mayoclinic.org/drugs-supplements/cephalexin-oral-route/side-effects/drg-20073325?p=1 |website=Mayo Clinic |publisher=Mayo Foundation for Medical Education and Research |access-date=14 November 2022}}</ref> [[Alcohol (drug)|Alcohol]] consumption reduces the rate at which it is absorbed.<ref>{{cite journal | vauthors = Barrio Lera JP, Alvarez AI, Prieto JG | title = Effects of ethanol on the pharmacokinetics of cephalexin and cefadroxil in the rat | journal = Journal of Pharmaceutical Sciences | volume = 80 | issue = 6 | pages = 511–516 | date = June 1991 | pmid = 1941538 | doi = 10.1002/jps.2600800602 }}</ref> Cefalexin also interacts with [[metformin]], an [[antidiabetic drug]],<ref name=AHFS2014/> and this can lead to higher concentrations of metformin in the body.<ref name=AHFS2014/><ref>{{cite journal | vauthors = Jayasagar G, Krishna Kumar M, Chandrasekhar K, Madhusudan Rao C, Madhusudan Rao Y | title = Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers | journal = Drug Metabolism and Drug Interactions | volume = 19 | issue = 1 | pages = 41–48 | year = 2002 | pmid = 12222753 | doi = 10.1515/dmdi.2002.19.1.41 | s2cid = 26919498 }}</ref> [[H2 receptor antagonist|Histamine H<sub>2</sub> receptor antagonist]]s like [[cimetidine]] and [[ranitidine]] may reduce the [[efficacy]] of cefalexin by delaying its [[absorption (pharmacokinetics)|absorption]] and altering its antimicrobial [[pharmacodynamics]].<ref name="GraysonCosgrove2017" /> Zinc and zinc supplements also interact with cefalexin and may reduce the amount of cefalexin in the body.<ref name="auto"/>