Editing Cell-mediated immunity (section)

==Development of cells==
All type 1 cells begin their development from the [[common lymphoid progenitor]] (CLp) which then differentiates to become the common innate lymphoid progenitor (CILp) and the t-cell progenitor (Tp) through the process of [[lymphopoiesis]].<ref name="The 3 major types of innate and adaptive cell-mediated effector immunity." /><ref name="Innate lymphocytes-lineage, localization and timing of differentiation">{{cite journal |last1=Kansler |first1=Emily R. |last2=Li |first2=Ming O. |title=Innate lymphocytes—lineage, localization and timing of differentiation |journal=Cellular & Molecular Immunology |date=July 2019 |volume=16 |issue=7 |pages=627–633 |doi=10.1038/s41423-019-0211-7|pmid=30804475 |pmc=6804950 |doi-access=free }}</ref>

Common innate lymphoid progenitors may then be differentiated into a natural killer progenitor (NKp) or a common helper like innate lymphoid progenitor (CHILp). NKp cells may then be induced to differentiate into [[natural killer cell]]s by [[Interleukin 15|IL-15]]. CHILp cells may be induced to differentiate into [[ILC1]] cells by [[Interleukin 15|IL-15]], into [[ILC2]] cells by [[Interleukin 7|IL-7]] or [[ILC3]] cells by [[Interleukin 7|IL-7]] as well.<ref name="The 3 major types of innate and adaptive cell-mediated effector immunity." /><ref name="Innate lymphocytes-lineage, localization and timing of differentiation" />

T-cell progenitors may differentiate into naïve CD8<sup>+</sup> cells or naïve CD4<sup>+</sup> cells. Naïve CD8<sup>+</sup> cells may then further differentiate into T<sub>C</sub>1 cells upon [[Interleukin 12|IL-12]] exposure, [IL-4] can induce the differentiation into T<sub>C</sub>2 cells and [[Interleukin 1|IL-1]] or [[Interleukin 23|IL-23]] can induce the differentiation into T<sub>C</sub>17 cells. Naïve CD4<sup>+</sup> cells may differentiate into T<sub>H</sub>1 cells upon [[Interleukin 12|IL-12]] exposure, T<sub>H</sub>2 upon [[Interleukin 4|IL-4]] exposure or T<sub>H</sub>17 upon [[Interleukin 1|IL-1]] or [[Interleukin 23|IL-23]] exposure.<ref name="The 3 major types of innate and adaptive cell-mediated effector immunity." /><ref name="Innate lymphocytes-lineage, localization and timing of differentiation" />