Editing Clonal anergy (section)

==Dominant tolerance==
Dominant and recessive tolerance are forms of a [[peripheral tolerance]] (the other tolerance beside peripheral is a [[central tolerance]]). Where so called recessive tolerance is associated with anergized lymphocytes as described above, in the dominant form of tolerance, specialized [[Regulatory T cell|T-reg cells]] which actively ablate the immune response are developed from the naive [[T cell|T lymphocyte]]. Similarly to recessive tolerance, unopposed [[NFAT]] signalling is also important for
[[Regulatory T cell|T-reg]] induction. In this case, the [[NFAT]] pathway activates another transcription factor – [[FOXP3]]<ref name="Tone et al">{{cite journal | vauthors = Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M | title = Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer | journal = Nature Immunology | volume = 9 | issue = 2 | pages = 194–202 | date = February 2008 | pmid = 18157133 | doi = 10.1038/ni1549 | s2cid = 7005085 }}</ref> that is a marker of [[Regulatory T cell|T-regs]] and participates in their genetic program.<ref name="Rudensky et al"/><ref name="Hermann-Kleiter N. and Baier G.">{{cite journal | vauthors = Hermann-Kleiter N, Baier G | title = NFAT pulls the strings during CD4+ T helper cell effector functions | journal = Blood | volume = 115 | issue = 15 | pages = 2989–2997 | date = April 2010 | pmid = 20103781 | doi = 10.1182/blood-2009-10-233585 | doi-access = free }}</ref>