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Clostridium perfringens
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=== Regulation of gliding motility: The CpAL/VirSR system === Some strains of ''C. perfringens'' cause various diseases like gas gangrene and myonecrosis. Toxins produced that are required for myonecrosis is regulated by the ''C. perfringens'' Agr-like (CpAl) system through the VirSR two-component system. The CpAL/VirSR system is a quorum sensing system encoded by other pathogenic clostridia. Myonecrosis starts at the infection site and involves bacteria migrating deeper via gliding motility. Researchers investigated if the CpAL/VirSR system regulates gliding motility. The study demonstrated that the CpAL/VirSR regulates ''C. perfringens'' gliding motility. Additionally, the study suggests that gliding bacteria in myonecrosis have increased transcription of toxin genes.<ref name=":1" />
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