Editing Cramp (section)

===Cramps caused by treatments===
Various medications may cause nocturnal leg cramps:<ref name=":0"/><ref name="pmid22157068">{{cite journal | vauthors = Garrison SR, Dormuth CR, Morrow RL, Carney GA, Khan KM | title = Nocturnal leg cramps and prescription use that precedes them: a sequence symmetry analysis | journal = Arch. Intern. Med. | volume = 172 | issue = 2 | pages = 120–6 | date = January 2012 | pmid = 22157068 | doi = 10.1001/archinternmed.2011.1029 | doi-access =  }}</ref>
* [[Diuretics]], especially potassium-sparing
* Intravenous (IV) [[iron sucrose]]
* [[Conjugated estrogens]]
* [[Teriparatide]]
* [[Naproxen]]
* [[Raloxifene]]
* Long-acting [[adrenergic beta-agonists]] (LABAs)
* Hydroxymethylglutaryl-coenzyme A reductase inhibitors (HMG-CoA inhibitors or [[statins]])

[[Statin]]s may sometimes cause [[myalgia]] and cramps among other possible side effects. [[Raloxifene]] (Evista) is a medication associated with a high incidence of leg cramps. Additional factors, that increase the probability of these side effects, are physical exercise, age, history of cramps, and [[hypothyroidism]]. Up to 80% of athletes using statins experience significant adverse muscular effects, including cramps;<ref>
{{cite journal |vauthors=Sinzinger H, O'Grady J |title=Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems |journal=Br J Clin Pharmacol |volume=57 |issue=4 |pages=525–8 |year=2004 |pmid=15025753 |doi=10.1111/j.1365-2125.2003.02044.x |pmc=1884475}}</ref> the rate appears to be approximately 10–25% in a typical statin-using population.<ref>
{{cite journal |vauthors=Bruckert E, Hayem G, Dejager S, Yau C, Bégaud B |title=Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients—the PRIMO study |journal=Cardiovasc Drugs Ther |volume=19 |issue=6 |pages=403–14 |year=2005 |pmid=16453090 |doi=10.1007/s10557-005-5686-z|s2cid=24525127 }}</ref><ref>
{{cite journal |title=Statin-induced apoptosis and skeletal myopathy |journal=Am. J. Physiol., Cell Physiol. |volume=291 |issue=6 |pages=C1208–12 |year=2006 |pmid=16885396 |doi=10.1152/ajpcell.00226.2006 |author=Dirks, A. J. |last2=Jones |first2=KM|s2cid=13313618 }}</ref> In some cases, adverse effects disappear after switching to a different statin; however, they should not be ignored if they persist, as they can, in rare cases, develop into more serious problems. [[Coenzyme Q10]] supplementation can help avoid some statin-related adverse effects, but currently, there is not enough evidence to prove its effectiveness in avoiding myopathy or myalgia.<ref>{{cite journal |vauthors=Lamperti C, Naini AB, Lucchini V |title=Muscle coenzyme Q10 level in statin-related myopathy |journal=Arch. Neurol. |volume=62 |issue=11 |pages=1709–12 |year=2005 |pmid=16286544 |doi=10.1001/archneur.62.11.1709|display-authors=etal|doi-access= }}</ref>