Editing Digitoxin (section)

==Interactions==
Drugs that can increase digitoxin toxicity include:<ref name="AC" />
* calcium
* substances that lower potassium or magnesium levels, such as [[diuretic]]s and [[corticosteroid]]s
* [[enzyme inhibitor|inhibitors]] of the liver enzyme [[CYP3A4]], which slow down digitoxin [[metabolism]]; examples are the antibiotic [[clarithromycin]], the antifungal [[itraconazole]], and [[grapefruit juice]]
* inhibitors of the transporter protein [[P-gp]], such as clarithromycin
* [[Beta blocker]]s add to the [[bradycardia]] (slow heartbeat) caused by digitoxin.

Drugs that can decrease the effectivity of digitoxin include:<ref name="AC" />
* substances that increase potassium levels, such as [[potassium sparing diuretic]]s
* [[enzyme inducer|inducers]] of CYP3A4 or P-gp, such as [[phenytoin]], [[rifampicin]] and [[St John's Wort]]
* substances that bind digitoxin in the gut, such as aluminium containing [[antacid]]s or [[colestyramine]]