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Doxylamine
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===Available forms=== {{See also|Pyridoxine/doxylamine}} Doxylamine is used medically as doxylamine succinate, the [[succinate]] [[salt (chemistry)|salt]] of doxylamine, and is available both alone (brand names Decapryn, Doxy-Sleep-Aid, Unisom) and in combination with [[pyridoxine]] (a form of [[vitamin B6|vitamin B<sub>6</sub>]]) (brand names Bendectin, Bonjesta, Diclegis).<ref name="Drugs@FDA">{{cite web | title=Drugs@FDA: FDA-Approved Drugs | website=accessdata.fda.gov | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm | archive-url=https://web.archive.org/web/20161104020633/http://www.accessdata.fda.gov/scripts/cder/daf/index.cfm | url-status=dead | archive-date=4 November 2016 | access-date=23 August 2022}}</ref> Doxylamine is available alone as [[immediate-release]] [[oral administration|oral]] [[tablet (pharmacy)|tablet]]s containing 25{{nbsp}}mg doxylamine succinate.<ref name="Drugs@FDA" /> Oral tablets containing 12.5{{nbsp}}mg doxylamine succinate as well as oral [[capsule (pharmacy)|capsule]]s containing 25{{nbsp}}mg doxylamine succinate were also previously available but were discontinued.<ref name="Drugs@FDA" /> The [[pyridoxine/doxylamine|combination of doxylamine and pyridoxine]] is available in the form of [[extended-release|extended-]] and [[delayed-release (pharmacy)|delayed-release]] oral tablets containing 10 to 20{{nbsp}}mg doxylamine succinate and 10 to 20{{nbsp}}mg pyridoxine hydrochloride.<ref name="Drugs@FDA" /> Doxylamine alone is available [[over-the-counter]], whereas doxylamine in combination with pyridoxine is a [[prescription-only medication]].<ref name="Drugs@FDA" /> Doxylamine is also available in over-the-counter nighttime [[cold medicine]] products such as NyQuil Cold & Flu (contains [[acetaminophen]], doxylamine succinate 6.25 to 12.5{{nbsp}}mg, and [[dextromethorphan hydrobromide]]), where it serves as the sedating component.<ref name="DailyMed-NyQuil">{{cite web | url=https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=620bc3dc-099b-40bd-be22-e4c3f9c8e09d | work = DailyMed | title = VICKS NYQUIL COLD AND FLU - acetaminophen, dextromethorphan hydrobromide, and doxylamine succinate capsule, liquid filled | publisher = U.S. National Library of Medicine }}</ref><ref name="GoodRx-NyQuil">{{cite web | url=https://www.goodrx.com/nyquil/what-is | title=Nyquil Cold and Flu: Basics, Side Effects & Reviews }}</ref>
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