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Drug tolerance
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==Behavioral tolerance== Behavioral tolerance occurs with the use of certain psychoactive drugs, where tolerance to a behavioral effect of a drug, such as increased motor activity by methamphetamine, occurs with repeated use. It may occur through drug-independent learning or as a form of pharmacodynamic tolerance in the brain; the former mechanism of behavioral tolerance occurs when one learns how to actively overcome drug-induced impairment through practice. Behavioral tolerance is often context-dependent, meaning tolerance depends on the environment in which the drug is administered, and not on the drug itself.<ref>{{Cite journal|last=Wolgin|first=D. L|date=2000-05-01|title=Contingent tolerance to amphetamine hypophagia: new insights into the role of environmental context in the expression of stereotypy|journal=Neuroscience & Biobehavioral Reviews|volume=24|issue=3|pages=279β294|doi=10.1016/S0149-7634(99)00070-6|pmid=10781692|s2cid=24570169}}</ref> [[Behavioral sensitization]] describes the opposite phenomenon.
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