Editing Endosome (section)

===Golgi to/from endosomes===

Vesicles pass between the Golgi and endosomes in both directions. The [[GGA1|GGAs]] and [[AP1G1|AP-1]] [[clathrin-coated vesicle]] adaptors make vesicles at the Golgi that carry molecules to endosomes.<ref name="Ghosh-2004">{{cite journal | vauthors = Ghosh P, Kornfeld S | title = The GGA proteins: key players in protein sorting at the trans-Golgi network | journal = European Journal of Cell Biology | volume = 83 | issue = 6 | pages = 257–62 | date = July 2004 | pmid = 15511083 | doi = 10.1078/0171-9335-00374 }}</ref> In the opposite direction, [[retromer]] generates vesicles at early endosomes that carry molecules back to the Golgi. Some studies describe a retrograde traffic pathway from late endosomes to the Golgi that is mediated by [[Rab (G-protein)|Rab9]] and [[TIP47]], but other studies dispute these findings. Molecules that follow these pathways include the mannose-6-phosphate receptors that carry lysosomal hydrolases to the endocytic pathway. The hydrolases are released in the acidic environment of endosomes, and the receptor is retrieved to the Golgi by retromer and Rab9.