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Factor X
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==Therapeutic use== Factor X is part of [[fresh frozen plasma]] and the prothrombinase complex. There are two commercially available Factor X concentrates: "Factor X P Behring" manufactured by [[CSL Behring]],<ref>{{cite book | vauthors = Brooker M | date = April 2008 | title = Registry of Clotting Factor Concentrates | edition = Eighth | publisher = [[World Federation of Hemophilia]] }}</ref> and high purity Factor X '''Coagadex''' produced by [[Bio Products Laboratory]] and approved for use in the United States by the FDA in October 2015, and in the EU in March 2016, after earlier acceptance by CHMP and COMP.<ref>{{Cite press release|title = FDA approves first Factor X concentrate to treat patients with rare hereditary bleeding disorder|date = October 20, 2015|publisher = US FDA|url = https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468038.htm|access-date = October 21, 2015|quote = Until today's orphan drug approval, no specific coagulation factor replacement therapy was available for patients with hereditary Factor X deficiency.|archive-url = https://web.archive.org/web/20151021125552/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm468038.htm|archive-date = October 21, 2015|url-status = dead}}</ref><ref>{{cite web | title=Coagadex | website=U.S. Food and Drug Administration | url=https://www.fda.gov/vaccines-blood-biologics/approved-blood-products/coagadex | date=28 June 2017 | archive-date=22 July 2017 | archive-url=https://wayback.archive-it.org/7993/20170722071352/https://www.fda.gov/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/ucm468110.htm | url-status=unfit | access-date=2 April 2020}}</ref><ref>{{cite web | title=Coagadex | website=U.S. Food and Drug Administration | date=21 September 2018 | url=http://www.fda.gov/vaccines-blood-biologics/approved-blood-products/coagadex | access-date=2 April 2020 | archive-url=https://web.archive.org/web/20191217011130/https://www.fda.gov/vaccines-blood-biologics/approved-blood-products/coagadex | archive-date=17 December 2019 | url-status=dead }}</ref><ref>{{cite web | title=Coagadex EPAR | website=[[European Medicines Agency]] (EMA) | date=17 September 2018 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/coagadex | access-date=21 April 2020 | archive-date=30 December 2019 | archive-url=https://web.archive.org/web/20191230151948/https://www.ema.europa.eu/en/medicines/human/EPAR/coagadex | url-status=live }}</ref> Kcentra, manufactured by CSL Behring, is a concentrate containing coagulation Factors II, VII, IX and X, and antithrombotic Proteins C and S.<ref>{{cite web | title=Kcentra- prothrombin, coagulation factor vii human, coagulation factor ix human, coagulation factor x human, protein c, protein s human, and water kit | website=DailyMed | date=22 October 2018 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=eee1afb8-324c-42e4-8bf0-f0c9da5e6d42 | access-date=21 April 2020 | archive-date=25 March 2021 | archive-url=https://web.archive.org/web/20210325112536/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=eee1afb8-324c-42e4-8bf0-f0c9da5e6d42 | url-status=live }}</ref>
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