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Folding@home
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=== Huntington's disease === [[Huntington's disease]] is a neurodegenerative [[genetic disorder]] that is associated with protein misfolding and aggregation. [[Polyglutamine tract|Excessive repeats]] of the [[glutamine]] amino acid at the [[N-terminus]] of the [[huntingtin protein]] cause aggregation, and although the behavior of the repeats is not completely understood, it does lead to the cognitive decline associated with the disease.<ref name="10.1016/S0140-6736(07)60111-1"/> As with other aggregates, there is difficulty in experimentally determining its structure.<ref name="10.1016/j.jmb.2009.01.032"/> Scientists are using Folding@home to study the structure of the huntingtin protein aggregate and to predict how it forms, assisting with [[rational drug design]] methods to stop the aggregate formation.<ref name="diseases FAQ"/> The N17 fragment of the huntingtin protein accelerates this aggregation, and while there have been several mechanisms proposed, its exact role in this process remains largely unknown.<ref name="10.1038/nchembio.279"/> Folding@home has simulated this and other fragments to clarify their roles in the disease.<ref name="forum: 8021 in beta"/> Since 2008, its drug design methods for Alzheimer's disease have been applied to Huntington's.<ref name="diseases FAQ"/>
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