Editing Forward genetics (section)

=== Insertional mutagenesis ===
Mutations can also be generated by [[insertional mutagenesis]]. Most often, insertional mutagenesis involves the use of transposons, which introduces dramatic changes in the genome of an organism. Transposon movements can create random mutations in the DNA sequence by changing its position within a genome, therefore modifying gene function, and altering the organism’s genetic information. For example, [[transposable elements]] containing a [[Genetic marker|marker]] are mobilized into the genome at random. These transposons are often modified to transpose only once, and once inserted into the genome a selectable marker can be used to identify the mutagenized individuals. Since a known fragment of DNA was inserted this can make mapping and cloning the gene much easier.<ref name="parsch" /><ref name="gfgtg">{{cite book |last1=Hartwell |first1=Leland |title=Genetics from genes to genomes |date=2010-09-14 |publisher=McGraw-Hill |isbn=978-0-07-352526-6 |edition=Fourth |location=New York, NY |page=G-11 |name-list-style=vanc}}</ref>