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Frameshift mutation
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===Codon-triplet importance=== {{Main article|Genetic code}} [[File:RNA-codons-aminoacids.svg|300px|thumb|The three letter code, the [[codon]]]] A [[codon]] is a set of three [[nucleotides]], a triplet that codes for a certain [[amino acid]]. The first codon establishes the reading frame, whereby a new codon begins. A protein's amino acid backbone [[sequence]] is defined by contiguous triplets.<ref name=Cox08>{{cite book |last1=Cox |first1=Michael |last2=Nelson |first2=David R. |last3=Lehninger |first3=Albert L |title=Lehninger principles of biochemistry |publisher=W.H. Freeman |location=San Francisco |year=2008 |isbn=978-0-7167-7108-1 |url-access=registration |url=https://archive.org/details/lehningerprincip00lehn_1 }}</ref> Codons are key to translation of genetic information for the synthesis of proteins. The reading frame is set when translating the mRNA begins and is maintained as it reads one triplet to the next. The reading of the genetic code is subject to three rules the monitor codons in mRNA. First, codons are read in a 5' to 3' direction. Second, codons are nonoverlapping and the message has no gaps. The last rule, as stated above, that the message is translated in a fixed reading frame.<ref name=MBoG_6th_2008/> [[File:Point Mutation.jpg|250px|thumb|Example of different types of point mutations]] <!-- Deleted image removed: [[File:Frameshift mutations.jpg|250px|thumb|Example of amino acid changes in frameshift mutation]] -->
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