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==''Code of Federal Regulations''== The ''[[Code of Federal Regulations]]'', revised {{as of|2020|April|1|lc=y|df=US}},<ref>{{cite web |url=https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=50&showFR=1 |title=CRF revised statutes: Protection of human subjects, general provisions|publisher=US Food and Drug Administration, Code of Federal Regulations|date=1 April 2020 |access-date= 30 January 2021}}</ref> includes (CFR) title 21 170.30(b) that provides general recognition of safety through scientific procedures requires the same quantity and quality of scientific evidence needed to obtain approval of the substance as a food additive.<ref>{{cite web|url=https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-summary-table-recommended-toxicological-testing-additives-used-food |archive-url=https://web.archive.org/web/20190906113326/https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-summary-table-recommended-toxicological-testing-additives-used-food |url-status=dead |archive-date=6 September 2019 |title=Guidance for Industry: Summary Table of Recommended Toxicological Testing for Additives Used in Food (June 2006, updated periodically) |publisher=US Food and Drug Administration |date=2020-09-20|access-date=2021-01-30}}</ref> and ordinarily is based upon published studies, which may be corroborated by unpublished studies and other data and information.<ref name=GRASfda/>
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