Editing Glycogenolysis (section)

==Regulation==
Glycogenolysis is regulated hormonally in response to blood sugar levels by [[glucagon]] and [[insulin]], and stimulated by [[epinephrine]] during the [[fight-or-flight response]]. Insulin potently inhibits glycogenolysis.<ref name="pmid31377934">{{cite journal | vauthors=Sargsyan A, Herman MA | title=Regulation of Glucose Production in the Pathogenesis of Type 2 Diabetes | journal=[[Current Diabetes Reports]] | volume=19 | issue=9 | pages=77 | year=2019 |  doi = 10.1007/s11892-019-1195-5 | pmc = 6834297 |  pmid=31377934}}</ref>

In myocytes, glycogen degradation may also be stimulated by neural signals;<ref>{{cite book|title=Molecular Cell Biology|edition=6th|last=Lodish|year=2007|publisher=W. H. Freeman and Company|isbn=978-1-4292-0314-2|page=658|display-authors=etal}}</ref> glycogenolysis is regulated by epinephrine and calcium released by the [[sarcoplasmic reticulum]].<ref name=Vasudevan2016/>

Glucagon has no effect on muscle glycogenolysis.<ref name=Vasudevan2016/>

Calcium binds with [[calmodulin]] and the complex activates phosphorylase kinase.<ref name=Vasudevan2016/>