Editing Halothane (section)

==Pharmacology==
The exact mechanism of the action of general anaesthetics [[Theories of general anaesthetic action|has not been delineated]].<ref>{{cite web | vauthors = Perkins B |url=http://www.scientificamerican.com/article/how-does-anesthesia-work/ |title=How does anesthesia work? |publisher=[[Scientific American]] |date=7 February 2005 |access-date=30 June 2016}}</ref> Halothane activates [[GABAA receptor|GABA<sub>A</sub>]] and [[glycine receptor]]s.<ref name="HemmingsHopkins2006">{{cite book| vauthors = Hemmings HC, Hopkins PM |title=Foundations of Anesthesia: Basic Sciences for Clinical Practice|url=https://books.google.com/books?id=xaXu1wHmENoC&pg=PA292|year=2006|publisher=Elsevier Health Sciences|isbn=978-0-323-03707-5|pages=292–|url-status=live|archive-url=https://web.archive.org/web/20160430015130/https://books.google.com/books?id=xaXu1wHmENoC&pg=PA292|archive-date=30 April 2016}}</ref><ref name="BarashCullen2013">{{cite book| vauthors = Barash P, Cullen BF, Stoelting RK, Cahalan M, Stock CM, Ortega R |title=Clinical Anesthesia, 7e: Print + Ebook with Multimedia|url=https://books.google.com/books?id=exygUxEuxnIC&pg=PA116|date=7 February 2013|publisher=Lippincott Williams & Wilkins|isbn=978-1-4698-3027-8|pages=116–|url-status=live|archive-url=https://web.archive.org/web/20160617063751/https://books.google.com/books?id=exygUxEuxnIC&pg=PA116|archive-date=17 June 2016}}</ref> It also acts as an [[NMDA receptor antagonist]],<ref name="BarashCullen2013" /> inhibits [[nicotinic acetylcholine receptor|nACh]] and [[voltage-gated sodium channel]]s,<ref name="HemmingsHopkins2006" /><ref name="SchüttlerSchwilden2008">{{cite book| vauthors = Schüttler J, Schwilden H |title=Modern Anesthetics|url=https://books.google.com/books?id=JpkkWhPbh2QC&pg=PA70|date=8 January 2008|publisher=Springer |isbn=978-3-540-74806-9|pages=70–|url-status=live|archive-url=https://web.archive.org/web/20160501142907/https://books.google.com/books?id=JpkkWhPbh2QC&pg=PA70|archive-date=1 May 2016}}</ref> and activates [[5-HT3 receptor|5-HT<sub>3</sub>]] and [[tandem pore domain potassium channel|twin-pore K<sup>+</sup> channel]]s.<ref name="HemmingsHopkins2006" /><ref name="Bowery2006">{{cite book| vauthors = Bowery NG |title=Allosteric Receptor Modulation in Drug Targeting|url=https://books.google.com/books?id=WRfgvOKfZMcC&pg=PA143|date=19 June 2006|publisher=CRC Press|isbn=978-1-4200-1618-5|pages=143–|url-status=live|archive-url=https://web.archive.org/web/20160510001416/https://books.google.com/books?id=WRfgvOKfZMcC&pg=PA143|archive-date=10 May 2016}}</ref> It does not affect the [[AMPA receptor|AMPA]] or [[kainate receptor]]s.<ref name="BarashCullen2013" />