Editing Helicobacter pylori (section)

=== Proteome ===
The [[proteome]] of ''H. pylori'' has been systematically analyzed and more than 70% of its [[protein]]s have been detected by [[mass spectrometry]], and other methods. About 50% of the proteome has been quantified, informing of the number of protein copies in a typical cell.<ref>{{cite journal|date=2015-08-03|title=Stable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori|url=https://www.sciencedirect.com/science/article/abs/pii/S1874391915300099|journal=Journal of Proteomics|language=en|volume=126|pages=34–45|doi=10.1016/j.jprot.2015.05.011|issn=1874-3919|last1=Müller|first1=Stephan A.|last2=Pernitzsch|first2=Sandy R.|last3=Haange|first3=Sven-Bastiaan|last4=Uetz|first4=Peter|last5=von Bergen|first5=Martin|last6=Sharma|first6=Cynthia M.|last7=Kalkhof|first7=Stefan|pmid=25979772|s2cid=415255|access-date=26 July 2021|archive-date=27 July 2021|archive-url=https://web.archive.org/web/20210727071501/https://www.sciencedirect.com/science/article/abs/pii/S1874391915300099|url-status=live}}</ref>

Studies of the [[interactome]] have identified more than 3000 [[protein-protein interactions]]. This has provided information of how proteins interact with each other, either in stable [[protein complex]]es or in more dynamic, transient interactions, which can help to identify the functions of the protein. This in turn helps researchers to find out what the function of uncharacterized proteins is, e.g. when an uncharacterized protein interacts with several proteins of the [[ribosome]] (that is, it is likely also involved in ribosome function). About a third of all ~1,500 proteins in ''H. pylori'' remain uncharacterized and their function is largely unknown.<ref name="Wuchty">{{cite journal |vauthors=Wuchty S, Müller SA, Caufield JH, Häuser R, Aloy P, Kalkhof S, Uetz P |title=Proteome Data Improves Protein Function Prediction in the Interactome of Helicobacter pylori |journal=Mol Cell Proteomics |volume=17 |issue=5 |pages=961–973 |date=May 2018 |pmid=29414760 |pmc=5930399 |doi=10.1074/mcp.RA117.000474 |doi-access=free |url=}}</ref>