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Hereditary multiple exostoses
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=== Heparan sulfate connections === MHE stems from an inability to biosynthesize [[heparan sulfate]], a proteoglycan. As Cuellar et al. note: "[E]ncoding glycosyltransferases involved in the biosynthesis of ubiquitously expressed heparan sulphate (HS) chains, are associated with MHE."<ref>{{cite journal | vauthors = Cuellar A, Reddi AH | title = Cell biology of osteochondromas: bone morphogenic protein signalling and heparan sulphates | journal = International Orthopaedics | volume = 37 | issue = 8 | pages = 1591β1596 | date = August 2013 | pmid = 23771188 | pmc = 3728397 | doi = 10.1007/s00264-013-1906-5 }}</ref><ref>{{cite journal | vauthors = Jones KB, Pacifici M, Hilton MJ | title = Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research | journal = Connective Tissue Research | volume = 55 | issue = 2 | pages = 80β88 | date = April 2014 | pmid = 24409815 | doi = 10.3109/03008207.2013.867957 }}</ref>
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