Editing Interactome (section)

==Genetic interaction networks==
{{main|Genetic interaction network}}
Genes interact in the sense that they affect each other's function. For instance, a [[mutation]] may be harmless, but when it is combined with another mutation, the combination may turn out to be lethal. Such genes are said to "interact genetically". Genes that are connected in such a way form ''genetic interaction networks''. Some of the goals of these networks are: develop a functional map of a cell's processes, drug target identification using [[chemoproteomics]], and to predict the function of uncharacterized genes.

In 2010, the most "complete" gene interactome produced to date was compiled from about 5.4 million two-gene comparisons to describe "the interaction profiles for ~75% of all genes in the [[budding yeast]]", with ~170,000 gene interactions. The genes were grouped based on similar function so as to build a functional map of the cell's processes. Using this method the study was able to predict known gene functions better than any other genome-scale data set as well as adding functional information for genes that hadn't been previously described. From this model genetic interactions can be observed at multiple scales which will assist in the study of concepts such as gene conservation. Some of the observations made from this study are that there were twice as many [[Epistasis and functional genomics|negative as positive interactions]], negative interactions were more informative than positive interactions, and genes with more connections were more likely to result in lethality when disrupted.<ref name=yeast>{{cite journal |doi=10.1126/science.1180823 |author=Costanzo M |title=The genetic landscape of a cell |journal=Science |date=2010-01-22 |volume=327 |issue=5964 |pages=425–431 |pmid=20093466|pmc=5600254 |author2= Baryshnikova A |author3= Bellay J |display-authors=etal|bibcode=2010Sci...327..425C }}</ref>