Editing Lipodystrophy (section)

== Antiretroviral drugs ==
{{Main|HIV-associated lipodystrophy}}
Lipodystrophy can be a possible side effect of certain [[antiretroviral drug]]s. Lipoatrophy is most commonly seen in patients treated with thymidine analogues and other older HIV drug treatments such as the nucleoside reverse transcriptase inhibitors [NRTIs] <ref>{{cite journal |vauthors=Carr A, Workman C, Smith DE, Hoy J, Hudson J, Doong N, Martin A, Amin J, Freund J, Law M, Cooper DA |date=July 2002 |title=Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy: a randomized trial |journal=JAMA |volume=288 |issue=2 |pages=207–15 |doi=10.1001/jama.288.2.207 |pmid=12095385 |doi-access=free}}</ref> like zidovudine (AZT) and stavudine (d4T).<ref>{{cite journal |vauthors=John M, McKinnon EJ, James IR, Nolan DA, Herrmann SE, Moore CB, White AJ, Mallal SA |date=May 2003 |title=Randomized, controlled, 48-week study of switching stavudine and/or protease inhibitors to combivir/abacavir to prevent or reverse lipoatrophy in HIV-infected patients |journal=Journal of Acquired Immune Deficiency Syndromes |volume=33 |issue=1 |pages=29–33 |doi=10.1097/00126334-200305010-00005 |pmid=12792352 |s2cid=22845453 |doi-access=free}}</ref> Other lipodystrophies manifest as [[lipid]] redistribution, with excess, or lack of, fat in various regions of the body. This is often most noticeable in the face.  These include, but are not limited to, having sunken cheeks and/or "humps" on the back or back of the neck (also referred to as buffalo hump)<ref>[http://www.medicinenet.com/script/main/art.asp?articlekey=19678 Physical and Biochemical Changes in HIV Disease] Eric S. Daar, M.D. MedicineNet, Accessed 22 September 2007</ref> which also exhibits due to excess [[cortisol]] (a so-called "stress" hormone).